ysl 109 | Cytotoxic evaluation of YSL ysl 109 MDA-MB-231 and NIH-3T3 cell lines were cultured in 75 cm2 bottles in Dulbecco’s modified Eagle’s medium (DMEM Gibco, Life Technologies, . See more Weighing as little as 1.77 kg (3.90 lb), the XL Lv VideoProbe system can easily “view anywhere.”. GE’s XL Lv borescope utilizes LED illumination to display excellent image quality. You can save clear, accurate still images and motion video to the internal flash memory or removable USB ThumbDriveTM.
0 · Cytotoxic evaluation of YSL
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YSL-109 was synthesized in our laboratory following a previously reported method (Sixto-Lopez et al. 2020, 2021). Trichostatin A (TSA), a pan-HDAC inhibitor, was purchased from Enzo Life Sciences (Farmingdale, NY). See moreMDA-MB-231 and NIH-3T3 cell lines were cultured in 75 cm2 bottles in Dulbecco’s modified Eagle’s medium (DMEM Gibco, Life Technologies, . See more
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An in silico toxicological risk assessment was performed to predict the preclinical toxicological properties of YSL-109. To this end, ProTox-II (Banerjee et al. 2018), Lazar (lazy structure–activity relationships) (Maunz et al. 2013), T.E.S.T. (Toxicity Estimation Software . See moreFirst, cell lines were cultured in 75 cm2 bottles. Once the cells achieve an 80% of confluently, they were counted and 1 × 104 of cells were . See moreSix female CD-1 mice (20 ± 2 g) were obtained from the Facultad de Estudios Superiores Iztacala, UNAM (FES-Iztacala, UNAM). Animals were housed in a temperature and light . See more
YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames .
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YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames test, whereas YSL-109 did not show in vivo genotoxicity and its oral acute toxicity (LD 50) in CD-1 female mice was higher than 2000 mg/kg, which is .YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames test, whereas YSL-109 did not show in vivo genotoxicity and its oral acute toxicity (LD 50) in CD-1 female mice was higher than 2000 mg/kg, which is in agreement with our in silico predictions. YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames test, whereas YSL-109 did not show in vivo genotoxicity and its oral acute toxicity (LD50) in CD-1.3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line (MDA-MB231) showing an antiproliferative activity ( IC 50 = 50.34 ± 1.11 µM), whereas on broblast, it was lesser toxic.
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YSL-109 inhibited HDAC6 in a highly selective manner (0.537 nM) compared with HDAC8 and HDAC1, and showed 4000-fold selectivity (Table 4). Thus, YSL-109 is a highly selective HDAC6 inhibitor that is more potent than TSA (Fig. 6) or the other inhibitors that have been reported [7].
Therefore, in this work, an HDAC6 selective inhibitor, the (S)-4-butyl-N-(1-(hydroxyamino)-3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line (MDA-MB231) showing an antiproliferative activity (IC50 = 50.34 ± 1.11 µM), whereas on fibroblast, it was lesser toxic. Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations. Sixto-López Y1, Ordaz-Pichardo C2, Gómez-Vidal JA3, Rosales . Of all the compounds evaluated, YSL-109 showed the best activity against hepatocellular carcinoma (HepG2 cell line, IC 50 = 3.39 µM), breast cancer (MCF-7 cell line, IC 50 = 3.41 µM; HCC1954. An HDAC6 selective inhibitor, the (S)-4-butyl-N-(1-(hydroxyamino)-3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line showing an antiproliferative activity and the toxicological profile was explored.
Of all the compounds evaluated, YSL-109 showed the best activity against hepatocellular carcinoma (HepG2 cell line, IC50 cell line, IC50 = ic50 = 6.42 μM). 259.439 μM. = 3.41 μM) and.
YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames test, whereas YSL-109 did not show in vivo genotoxicity and its oral acute toxicity (LD 50) in CD-1 female mice was higher than 2000 mg/kg, which is .
YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames test, whereas YSL-109 did not show in vivo genotoxicity and its oral acute toxicity (LD 50) in CD-1 female mice was higher than 2000 mg/kg, which is in agreement with our in silico predictions. YSL-109 shows moderate mutagenic activity on TA-98 strain at 30 and 100 µM in the Ames test, whereas YSL-109 did not show in vivo genotoxicity and its oral acute toxicity (LD50) in CD-1.
Cytotoxic evaluation of YSL
3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line (MDA-MB231) showing an antiproliferative activity ( IC 50 = 50.34 ± 1.11 µM), whereas on broblast, it was lesser toxic. YSL-109 inhibited HDAC6 in a highly selective manner (0.537 nM) compared with HDAC8 and HDAC1, and showed 4000-fold selectivity (Table 4). Thus, YSL-109 is a highly selective HDAC6 inhibitor that is more potent than TSA (Fig. 6) or the other inhibitors that have been reported [7].
Therefore, in this work, an HDAC6 selective inhibitor, the (S)-4-butyl-N-(1-(hydroxyamino)-3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line (MDA-MB231) showing an antiproliferative activity (IC50 = 50.34 ± 1.11 µM), whereas on fibroblast, it was lesser toxic.
Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations. Sixto-López Y1, Ordaz-Pichardo C2, Gómez-Vidal JA3, Rosales . Of all the compounds evaluated, YSL-109 showed the best activity against hepatocellular carcinoma (HepG2 cell line, IC 50 = 3.39 µM), breast cancer (MCF-7 cell line, IC 50 = 3.41 µM; HCC1954. An HDAC6 selective inhibitor, the (S)-4-butyl-N-(1-(hydroxyamino)-3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line showing an antiproliferative activity and the toxicological profile was explored.
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ysl 109|Cytotoxic evaluation of YSL
